However, we observed that global deletion of RIPK3 in CreLysMCasp8flox/flox and CreCD11cCasp8flox/flox mice causes the response to K/BxN serum-transfer-induced arthritis to revert to that of Casp8flox/flox control mice, indicating that the aberrant responses observed require RIPK3 action. The gene discussed is RIPK3; the disease is arthritic joint disease.