A genome-wide association study meta-analysis in more than 100,000 subjects of European and Asian ancestry (29,880 were diagnosed with RA), evaluated nearly 10 million single-nucleotide polymorphisms (SNPs) and identified a SNP associated with risk of RA development within the locus containing the gene encoding for both caspase-8 and cFLIP [39]. Here, CASP8 is linked to rheumatoid arthritis.