Interestingly, Ting Dai et al. [38] showed that GOLPH3 promotes K63-linked polyubiquitination of Tumor necrosis factor receptor-associated factor 2, receptor interacting proteins, and NF-κB essential modulator and substantially sustained the activation of NF-κB in hepatocellular carcinoma (HCC) cells. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.