Recent findings demonstrated that HGF/c-Met signaling induced lysosome redistribution to the periphery of tumor cells leading to increased secretion of the lysosomal protease cathepsin B. This anterograde (microtubule plus end or outward) lysosome trafficking was necessary for HGF/c-Met-mediated tumor cell invasion and activated c-Met stimulated anterograde lysosome trafficking via signaling through phosphoinositide-3-kinase (PI3K) and sodium/hydrogen exchangers (NHEs) [15, 17]. The gene discussed is HGF; the disease is neoplasm.