A growing body of evidence highlights the relevance of atherogenic dyslipidaemia, characterised by increased triglyceride (TG)-rich lipoproteins and their remnants (for which elevated TGs are a metric), often with subnormal plasma concentrations of high-density lipoprotein cholesterol (HDL-C), and an increase in small dense LDL particle numbers, typically seen in insulin resistant conditions such as type 2 diabetes mellitus, as a contributor to lipid-related residual cardiovascular risk, as well as the risk of silent coronary artery disease [11–13]. Here, INS is linked to inherited lipid metabolism disorder.