Study has shown that the expression of MMP-2 and MMP-9 is closely related to cancer angiogenesis; tumor cells which can secrete MMP-2 and MMP-9 have high invasion and metastases ability, drugs can also be used to inhibit the growth of tumor cells through lowering the activity of MMP-2 and MMP-9 [41]. This evidence concerns the gene MMP9 and neoplasm.