Coincident with altered expression of cell-cycle regulators, the phosphorylation level of Rb, a downstream target protein level of CDK and an upstream regulator of FOXM1, was significantly decreased in miR-216b transfected cells and obviously increased in miR-216b inhibited cells (Fig. 3a), further confirming that miR-216b can affect the proliferation of cervical cancer cells by regulating FOXM1 related cell division factors. The gene discussed is RB1; the disease is cervical cancer.