GABBR1 and muscle cramp: GABA agonists, such as baclofen, can activate GABA β receptors, reduce the synaptic reflex potential of spinal synapses or multiple synapses and the reflex potential between posterior spinal roots, resulting in skeletal muscle relaxation, which can reduce the frequency and severity of spasm attack, thus relieving the spasm-related clonus, pain and muscle rigidity, etc [16].