In another two patients receiving 400 mg/day (cases #4 and #10), treatment was transiently stopped due to grade 4 neutropenia and grade 4 anemia which were successfully recovered with G-CSF support and red blood cell transfusions, respectively; afterward, imatinib was reintroduced in both cases at 300 mg/day with no further haematological toxicity. This evidence concerns the gene CSF3 and anemia (phenotype).