PIK3CA and colorectal carcinoma: Similarly, in CRC, 95.65% (22/23) of the samples were carrying 47 somatic mutations on multiple driver genes (Figure 5A), which mainly focused on the A-driver genes, KRAS (56.52%, 13/23) and PIK3CA (26.09%, 6/23), and on the LF-driver genes, TP53 (56.52%, 13/23), APC (39.13%, 9/23), and PTEN (8.7%, 2/23).