PARP1 and retinal degeneration: To determine whether drug-mediated PARP inhibition also protects against alkylation-induced retinal degeneration, we treated WT and AagTg mice with either Veliparib (10 mg/kg) or Olaparib (50 mg/kg) 1 hour prior to MMS injection (75 mg/kg), and then analyzed retinas 7 days (d) post-MMS.