PARP1 and cerebellar degeneration: Even so, protection against MMS-induced cerebellar degeneration after treatment with low doses of Olaparib (1 mg/kg) was still not at the level observed after Veliparb treatment (10 mg/kg) further suggesting that PARP inhibitors with less trapping activity, such as Veliparib, are more efficacious at preventing alkylation-induced neuronal degeneration.