Supporting these data, we detected the appearance of inhibitory PD-1/PDL-1 interactions, which corresponded to perivascular lymphocytic infiltration and pericytes respectively in GBM+Pc grafts (Supplementary Figure 3), and compared it to host pericytes, where we did not find those interactions though perivascular PDL- 1 expression was present (not shown). This evidence concerns the gene CD274 and glioblastoma.