The unique expression of CHOP in HIV-1 gp120 clade C and Bcl-2 in HIV-1 gp120 clade B reaffirm that HIV-1 gp120 proteins exert a clade dependent specific response in cell death through UPR activation in U87 astrocytoma cells. This evidence concerns the gene ITIH4 and astrocytoma (excluding glioblastoma).