In both cases, HIV-1 gp120 clade B treated astrocytoma cells showed higher gene expression (4.57fold ± 0.83) (Figure 5C) and relative increase in protein amount (2.28 ± 0.24) (Figure 5D) of this ER stress intermediate when compared to control. The gene discussed is ITIH4; the disease is astrocytoma (excluding glioblastoma).