Major histocompatibility complex I and II related proteins, tumor necrosis factor (TNF), interferon signaling were up-regulated by HIV-1 gp120 clade B, while HIV-1 gp120 clade C induced the expression of proteins involved in NF-kB signaling, indicating that HIV-1 gp120 proteins activate the immuno-recognition response in astrocytoma. The gene discussed is TNF; the disease is astrocytoma (excluding glioblastoma).