Pérez-Magán et al. [18] recently reported a gene expression profiling (GEP) signature of advanced and recurrent meningiomas, which included aberrant expression of genes of the Wnt pathway; thus, these authors found downregulation of SFRP1, a gene from the SFRPs (secreted frizzled-related proteins) protein family which are able to down-regulate Wnt signaling, in recurrent and atypical meningiomas. The gene discussed is SFRP1; the disease is meningioma.