TNF and acute myeloid leukemia: To this end, we investigated the effect of Sorafenib on BV6-induced apoptosis in RIP3-deficient and therefore necroptosis-resistant NB4 AML cells as well as in Jurkat wild-type cells, which have previously been shown to undergo apoptosis upon BV6/TNFα treatment that is blocked by the caspase inhibitor zVAD.fmk [17, 26].