We investigated SDF-1α-induced transmigration of both mesothelioma cell lines through membranes coated with collagen I and IV following single doses of photon irradiation (1 Gy and 2 Gy): Irradiation of both H28 and H226 cells with single photon doses of 1 Gy and 2 Gy increased transmigration through collagen I- and collagen IV-coated filters. The gene discussed is CXCL12; the disease is mesothelioma.