PKM and thymus lymphoma: Western blotting confirmed that PKM2 was overexpressed 2.5 fold in the thymic lymphoma of FIR+/−TP53−/− mice compared with FIR+/+TP53−/− mice (p = 0.002) (Figure 3A, 3B), while PKM2 mRNA was elevated approximately twice more in the thymic lymphoma of FIR+/−TP53−/− mice than the FIR+/+TP53−/− mice (Figure 3C).