Our results exhibited that OA suppressed p-mTOR (Ser2448) and increased the levels of p-AMPKα (Thr172) and p-ULK1 (Ser317), indicating that AMPK-mTOR-ULK1 pathway might take part in OA-induced autophagy in bladder cancer cells. The gene discussed is MTOR; the disease is urinary bladder carcinoma.