In a previous study measuring the expression of 11 nAChR subunit genes in 66 NSCLC primary tumors (54 ADC-L/6 SQC-L/5 LCLC, 1 adenosquamous) surgically resected from Chinese patients, only two of the genes evaluated showed significant expression changes in the tumor (increased CHRNB4 and decreased CHRNA4) compared to expression levels in non-tumor tissues [29]. The gene discussed is CHRNA4; the disease is neoplasm.