Genes CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNA9, CHRNB2 and CHRNB4, located across different chromosomes, respectively encode for the α3, α4, α5, α6, α7, α9, β2 and β4 nAChR subunits expressed in lung cancer cells [see Ref. The gene discussed is CHRNA5; the disease is lung carcinoma.