In conclusion, the present study analyzed the associations between lncRNA expression and survival of ER-positive breast cancer patients and identified a novel lncRNA signature comprising six lncRNAs (HAGLR, STK4-AS1, DLEU7-AS1, LINC00957, LINC01614 and ITPR1-AS1) which can robustly predict the survival of breast cancer patients with ER-positive status. Here, ITPR1 is linked to breast cancer.