AKT1 and Parkinson disease: As shown in Figure 4(A), 4(B), and 4(C), both the western blot bands and quantify analysis revealed a significant decrease in the expression of CB1, CB2, Parkin, PINK1, p-PI3K, and p-AKT of PD mice compared to untreated control, both in the substantia nigra and hippocampus.