EGFR and non-small cell lung carcinoma: Since the third generation EGFI-TKI AZD9291 (Osimertinib) is highly effective in NSCLC patients with EGFR T790M mutation and has been approved by the US FDA [6, 7, 8], it is recommended that tumor tissue biopsy results be obtained to assess EGFR mutation status so that those patients can receive the appropriate treatment.