Also pre-treatment of NP8 tumor mice with anti-PD1/PD-L1 antibodies before transfer of H8N8 specific CTLs significantly increased the time of tumor outgrowth compared to transfer of H8N8 specific CTLs alone, although it was less effective than pre-treatment of NP8 tumor mice with 4 Gy irradiation (Figure 7B, lanes 6, 7). The gene discussed is CD274; the disease is neoplasm.