The forced expression of ABI3 in two follicular thyroid carcinoma cell lines (WRO and FTC 133) markedly decreased the phosphorylation of AKT at both T308 and S473, as well as the phosphorylation of the downstream-targeted protein pGSK3β at S9 (P<0.05) (Figure 1D). The gene discussed is AKT1; the disease is thyroid gland follicular carcinoma.