On univariate analysis, post-CRT distance from the anal verge (P = 0.005), post-CRT tumor size (P < 0.001), post-CRT circumferential extent of tumor (P < 0.001), tumor pathology (P < 0.001), pre-CRT CEA level (P = 0.001), and post-CRT CEA level (P < 0.001) were independently associated with pCR in LARC patients treated with nCRT and TME (Table 2). This evidence concerns the gene CEACAM5 and neoplasm.