HYAL2 and neoplasm: Hyaluronidases (HYALs) are key regulators of hyaluronan (HA) metabolism, and HYAL2 is known to be expressed in somatic tissue and blood cells and to initiate HA degradation [21], whereas HYAL1 expression in tumor tissue was recently found to be associated with endometrial carcinoma aggressiveness and described as an independent prognostic factor for early disease recurrence [22].