In addition, Dienstmann et al. have shown that SYM004 is highly efficient in blocking CRC cell growth in the presence of the high-affinity ligands EGF and TGFα, factors known to be both upregulated in response to anti-EGFR antibody treatment and potential determinants of EGFR inhibitor resistance [23]. The gene discussed is EGF; the disease is colorectal carcinoma.