We detected upregulation of several TCA metabolites, pointing out a direct association between sCPE and TCA, however extensive measurements of citrate, isocitrate, IDH enzymatic activity and alternative products of enzymatic reaction (such as 2-hydroxyglutarate) in the CPE model are lacking in our study and should be further investigated in order to answer the question if sCPE effects are also applicable to the IDH1/2-mutated GBM. Here, IDH2 is linked to glioblastoma.