Although the overexpression of the 6-O-sulfatases Sulf-1 and / or 2, which remove 6-O sulfates from the N-glucosamines of the HS fractions have been described to intensify Wnt pathway activity and oncogenic effects in human pancreatic tumor cells [39], hepatocellular carcinomas [40] or human prostate cancer cells [41], respectively, contrary findings also exist. This evidence concerns the gene SULF1 and Familial prostate cancer.