SLC7A11 and neoplasm: Interestingly, activated monocytes/macrophages share with tumor cells both the upregulation of xCT [14, 29] that occurs in response to ROS induced in inflammatory cells by PRR triggering [29] and the membrane expression of v-ATPases [30, 31], likely due to the need to extrude protons, as also activated macrophages undergo metabolic shift to aerobic glycolysis [32].