PLCG1 and chronic myelogenous leukemia, BCR-ABL1 positive: Markova B, et al. underscored the possible importance of PLC-γ1 in chronic myeloid leukemia (CML) leukemogenesis via a novel Akt-independent, PLC-γ1-driven mechanism of activation of mTOR/p70S6-K in BCR-ABL-positive cells [30].