In melanoma, monoubiquitinated H2A-K119 has previously been implicated in RNF2-mediated metastatic behavior through silencing of the LTBP2 promoter, whereas the growth-promoting potential of PCR1 factor RNF2 was independent of its E3 ubiquitin ligase activity via an interaction with histone acetylase p300 [27]. Here, EP300 is linked to melanoma.