Because TFs such as PAX3 and ETS1 have previously been identified to be important regulators in melanoma in part by activating expression of receptor tyrosine kinase c-MET [23], we subsequently performed ChIP assays of the PAX3, ETS and c-MET promoter region using an anti-MYSM1 antibody and chromatin derived from A375 cells. The gene discussed is ETS1; the disease is melanoma.