Compared with the first quintile, the fourth and the fifth quintile of the odds ratios (95% confidence intervals) for large cerebral artery stenosis were 1.26(1.03-6.77, p<0.05) and 4.71(1.45-15.26, p<0.05) after adjustment for age, sex, and smoking, hypertension, type 2 DM, Dyslipidemia, Cr, Urea, Uric acid, hcy, CRP. This evidence concerns the gene CRP and Hypertension.