MUC16 is a very large transmembrane protein whose mutation rate is relatively high in colon adenocarcinoma (COAD) and colon mucinous adenocarcinoma (COMA) cancers, LUAD, bladder urothelial carcinoma (BLCA), PDAC, and UEC (Figure 1E). Here, MUC16 is linked to colon mucinous adenocarcinoma.