Lédel F reported HER3+ was an independent negative prognostic factor for OS in the entire population of colorectal cancer patients and in the subgroup with colon cancer stage II, but not in stage III [16], it indicated that HER3+ status was not strong as a prognostic factor, and the prognostic value decreased when dividing the patients into subgroups. The gene discussed is ERBB3; the disease is malignant colon neoplasm.