Recently, the Cancer Genome Atlas Research Network published a comprehensive molecular characterization of gastric adenocarcinoma and classified EBV-associated GC (EBVaGC) as a distinct GC type that is characterized by recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2 and programmed death ligand-1/2 (PD-L1/PD-L2) [2]. This evidence concerns the gene CD274 and gastric adenocarcinoma.