Cellular migration and proliferation were systematically analyzed in functional assays, and significant (p≤0.001) MEOX2-dependent GLI-1 protein expression was present in A549 cells, which contrasted with non-detectable MEOX2 levels in the H1975 lung adenocarcinoma cell line (Figure 7A and Supplementary Figure 2C). Here, MEOX2 is linked to lung adenocarcinoma.