Additionally, HOTAIR overexpression has been detected in solid tumor NSCLC patients with poorer prognosis as well as functionally associated with higher lung tumor cellular migration and cellular invasion in vitro lung in A549 and SPC-A1 cancer cells, with lung tumor metastasis in vivo in SPC-A1 lung cancer cells [42], and with poorer prognosis in lung cancer patients [37, 38]. This evidence concerns the gene HOTAIR and lung cancer.