Here, we identified significant participation of the MEOX2-GLI1 axis in both cellular cytotoxic resistance capacity and cellular migration proliferation, which is likely explained in part by previous studies showing the involvement of the SHH-GLI1 signaling pathway in cellular proliferation, cellular transmigration and epithelial-mesenchymal transition in the NSCLC cell lines A549 and H520 [32]. This evidence concerns the gene SHH and non-small cell lung carcinoma.