We also validated the role of the MEOX2-GLI1 axis by performing transwell-migration vertical assays with both the A549 and NH2347 lung adenocarcinoma cell lines and observed significant differences (p≤0.001) compared with H1975 lung cancer cells (Figure 7B), which express non-detectable MEOX2 levels (Figure 7A and Supplementary Figure 2C). This evidence concerns the gene GLI1 and lung cancer.