HHIP and lung adenocarcinoma: Additionally, this mechanism is involved in lung adenocarcinoma cell survival and cancer drug resistance conducted via the SHH-GLI1 axis but negatively regulated by Hedgehog-Interacting Protein (HHIP) in EGFR-non-mutated A549 or EGFR-mutated H1975 and HCC827 NSCLC cell lines under TKI-based treatment [48]; however, here this mechanism is positively regulated by MEOX2 at the transcriptional level.