Additionally, we suggest the MEOX2 transcription factor promotes platinum-based treatment resistance at the Hedgehog-GLI1 gene promoter level, in accordance with a previous report describing the involvement of Hedgehog-GLI1 in the ABCG2 transporter-dependent oncological resistance exhibited by a lung cancer stem-like side cell population [26] and is involved maintaining the self-renewal of cancer stem-like cells as recently reported for arsenic trioxide-treated lung carcinoma cells [27]. This evidence concerns the gene MEOX2 and lung cancer.