Additionally, GLI-1 gene promoter sequences are transcriptionally occupied by active RNA Pol II and epigenetically accompanied by the active histones H3K27Ac and H3K4me3 with statistically significant enrichment at two hotspot regions ranging from −1,830 to −1673 and −822 to −665, supporting the existence of an active MEOX2-GLI1 axis, which was also indicated by the lung cancer epigenome analysis derived from A549 lung adenocarcinoma cells (Figure 1B and Figure 3B) previously published and deposited by Sabo PJ and colleagues in the ENCODE Project database [40]. Here, MEOX2 is linked to lung adenocarcinoma.