Similar effects were seen with siRNA-GLI1 or a mixture of siRNA-MEOX2 plus siRNA-GLI1 (Figure 6B), but no significant reduction in cellular viability occurred with either anti-MEOX2 or anti-GLI-1 siRNAs in an EGFR-mutated lung cancer cell line H1975 with non-detectable MEOX2 mRNA expression (Supplementary Figure 2C, Figure 6C). Here, EGFR is linked to lung cancer.