Our epigenome-wide data were directly obtained from human solid lung carcinomas and identified a range of 3,347 to 6,787 gene promoters (FDR≤0.2) representing several cell signaling pathways, including TGFb, WNT, Notch, Jak-STAT, MAPK, and mTOR; the involvement of some of these pathways in cancer progression, tumor cellular invasion and cancer metastasis has previously been described [24]. This evidence concerns the gene TGFB1 and neoplasm.