To further test if artificially increasing the NAD+/NADH ratio is sufficient to inhibit tumor growth, we expressed an NADH oxidase from Lactobacillus brevis (LbNOX) in DKO_1A1 (ALDH1A1/3A1 double knockout rescued with ALDH1A1) cells [18]. The gene discussed is ALDH1A1; the disease is neoplasm.