In humans or rodents, AR and aldo-keto reductase family 1B10 (AKR1B10, also known as AR-like-1), were often among the most significantly up-regulated genes in many types of cancers including cervical cancer, colon cancer, leukemia, pancreatic cancer and hepatocellular carcinoma (HCC) [4–11]. The gene discussed is AKR1B10; the disease is hepatocellular carcinoma.