The inverse relationship between CFTR and NFκB has also been found in male reproductive tract, where high temperature-downregulated CFTR with upregulated NFκB/COX2/PGE2 was found to be responsible for impaired testis-blood barrier, and thus disrupted spermatogenesis as seen in cryptorchidism [41]. The gene discussed is NFKB1; the disease is cryptorchidism.