Regarding PD-L1 expression on ICs, no significant correlation between primary tumors and metastases were shown (rs= 0.235; p= 0.239) with a high discordance rate of 44.4% (PD-L1 positivity tumor vs. metastasis: 77.7% vs. 44.4%), resulting in significant dynamic changes between primary tumor and metastasis (p=0.006). The gene discussed is CD274; the disease is neoplasm.