CD274 and neoplasm: On the contrary, a T-cell inflamed tumor microenvironment is associated with increased CD8+ T cell infiltration (Supplementary Figure 1), higher amount of tumor-infiltrating lymphocyte (TIL) clonality, which correlates with higher PD-L1 expression [8], higher mutation load [9] and consecutive radiographic response to checkpoint inhibitors such as atezolizumab [9], supporting an adaptive immune response-mechanism [8, 10].