KDR and melanoma: To exclude the possibility that the PDGF-C/NRP-1 effects observed in M14-N cells were the consequence of clonal variation, we analysed other M14-derived melanoma clones: M14-N14 (NRP-1 positive and VEGFR-2 negative); M14C2/MK18 and M14-NV (NRP-1 and VEGFR-2 positive); M14-C3 and M14-C (NRP-1 and VEGFR-2 negative) [5, 6, 9].