Despite advances in the therapy of the metastatic disease with the approval of immune checkpoints inhibitors (i.e. ipilimumab, pembrolizumab and nivolumab) and, for BRAF mutated melanomas, of BRAF and MEK inhibitors (vemurafenib, dabrafenib, trametinib, cobimetinib), melanoma patients diagnosed at advanced stages have low expectancy of life [1]. This evidence concerns the gene BRAF and metastatic neoplasm.