NRP-1 expression has been correlated with melanoma metastatic potential [5, 6, 9, 19, 20] and our findings on its activation by PDGF-C suggest that a PDGF-C/NRP-1 autocrine loop might sustain, at least in part, the aggressive phenotype of NRP-1 positive melanoma cells. This evidence concerns the gene PDGFC and melanoma.