We have tested the uptake of 4 types of exosomes derived from pancreatic adenocarcinoma lines BSp73AS (AS) of a rat expressing different tetraspanins by target cells in vitro and in vivo (exosomes from AS, AS-Tspan8, AS-Tspan8/CD9n, AS-Tspan8/Integrinβ4) [40]. Here, TSPAN8 is linked to pancreatic adenocarcinoma.