PRKAA1 and Hepatic fibrosis: In the mouse carbon tetrachloride (CCl4) model, treatment with the AMPK agonist 5-Aminoimidazole-4-carboxamide1-β-D-ribofuranoside (AICAR) suppressed HSC proliferation and collagen-α1 expression and correlated with attenuated hepatic fibrosis and improved liver function [41].