Jo and colleagues fed C57BL/6J mouse with a high-fat diet for 10 weeks and discovered that eugenol, an AMPK activator, ameliorated fatty acid-related hepatic fibrosis, concomitant with reduced expression of α-SMA, collagen I, and plasminogen activator inhibitor-1 (PAI-1). Here, SERPINE1 is linked to Hepatic fibrosis.