Several ERCC single nucleotide polymorphisms (SNPs) associated with osteosarcoma prognosis have been reported, including ERCC1 rs11615 (Asn118Asn) and rs3212986 (Gln504Lys), and ERCC2 rs13181 (Lys751Gln) and rs1799793 (Asp312Asn) [10–21]. Here, ERCC2 is linked to osteosarcoma.