In a prostate cancer cell model, it was reported that irradiation caused durable upregulation of cancer stem cell marker proteins, including aldehyde dehydrogenase 1A1 (ALDH1A1) as well as long-term altered histone methylation patterns of H3K4, H3K36, and H3K27 tri-methylation [73]. The gene discussed is ALDH1A1; the disease is Familial prostate cancer.