SIRT1 and hepatocellular carcinoma: For hepatocellular carcinoma (3 studies, 425 patients) and gastric cancer (3 studies, 318 patients), high SIRT1 expression was also significantly associated with worse OS (hepatocellular carcinoma: sHR 1.53, 95% CI = 1.16-2.01; gastric cancer: sHR 3.19, 95% CI = 1.97-5.16) with no heterogeneity (hepatocellular carcinoma: I2 = 10.9%, Ph = 0.326; gastric cancer: I2 = 5.7%, Ph = 0.346) (Table 3).