A further subgroup analysis of Asian patients according to cancer type showed that there was a significant association between SIRT1 and worse OS in non-colorectal gastrointestinal cancer (sHR 1.86, 95% CI = 1.50-2.30), but not in colorectal cancer (sHR 1.30, 95% CI =0.78-2.18). This evidence concerns the gene SIRT1 and cancer.