SIRT1 and non-small cell lung carcinoma: SIRT1 increases vessel density through facilitating endothelial cell branching and proliferation and promotes lung tumor growth through down-regulation of DLL4/Notch signaling and deacetylation of Notch1 intracellular domain [18], the Inactivation of SIRT1 can exert its antitumor activities through the tumor suppressor p27 in NSCLC [19].