IL-10 gene promoter region is highly polymorphic, and three promoter single nucleotide polymorphisms (SNPs) such as -1082A/G (rs1800896), -819T/C (rs1800871) and -592A/C (rs1800872) have been reported to regulate IL-10 expression [11, 12] and alter the susceptibility to various types of cancers [13–16]. The gene discussed is IL10; the disease is cancer.