IL10 and cancer: Substantial heterogeneities were found among all studies regarding IL-10 -1082A/G polymorphism and overall cancer risk (homozygous: P = 0.025; heterozygous: P < 0.001; dominant: P < 0.001 and allele comparison: P < 0.001), but not under the recessive model (P = 0.242) (Table 2).