IL10 and cancer: For the studies assessing three polymorphisms (-1082A/G, -819T/C and -592A/C) [32, 37], two (-1082A/G and -592A/C) [31], only one such as -1082A/G [29, 30, 33-35, 38] or -819T/C [36, 39] polymorphism and cancer risk but no other IL-10 gene polymorphisms, the genotypes distribution in the controls were deviated from HWE, thus, these studies were excluded in the final analysis.