These data indicate that CTCF may promote ovarian cancer metastasis by broadly regulating the expression of metastasis-associated genes, notably CTBP1, SERPINE1 and SRC. In order to further elucidate the details of the underlying mechanisms, we used ChIP-seq technology to identify the genomic locations bound by CTCF in Skov3 cells. This evidence concerns the gene SERPINE1 and ovarian cancer.