To determine if other genes involved in breast cancer could mediate changes in HSD17B1 or HSD17B2 expression, we analyzed the effect of downregulation of GREB1, HRAS, PRKCZ, CX3CL1, EPHB6, KLK5, TP63, and TRIM29 on HSD17B1 and HSD17B2 gene expression. This evidence concerns the gene KLK5 and breast carcinoma.